![]() The disease time course was divided into 2 periods: the first 6 months after onset of the drug reaction (early phase) and the period thereafter (late phase). In all, 34 patients were classified into 2 groups: 14 patients with oral corticosteroid treatment and 20 with noncorticosteroid treatment. The aim of this study was to retrospectively analyze complications and sequelae in the early and late phases of DIHS/DRESS according to treatment. ![]() Although recent reports have documented the development of autoimmune disease after complete resolution of DIHS/DRESS, relatively little is known about long-term outcomes after complete resolution of the disease. Drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe systemic hypersensitivity reaction caused by specific drugs, in which herpesvirus reactivations and organ dysfunction occur during the course of the disease.
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